Reinhardt lab establishes a new paradigm how extracellular fibrillin-1 regulates intracellular microRNAs and cell function
Fibrillins are the major components of microfibrils in the extracellular matrix of elastic and non-elastic tissues. Fibrillin-1 contains one evolutionarily conserved RGD sequence that mediates cell–matrix interactions through cell-surface integrins. The Reinhardt lab presents a novel paradigm how extracellular fibrillin-1 controls cellular function through integrin-mediated microRNA regulation.
A new collaboration between the Reinhardt group and the Mantovani group at Laval University leads to the production of physiological-like vascular scaffolds published in Biomaterials.
One of the tightest bottlenecks in vascular tissue engineering is the lack of strength and elasticity of engineered vascular wall models caused by limited elastic fiber deposition. In this study, collagen gel-based scaffolds were cellularised with vascular smooth muscle cells (SMCs) and supplemented with human plasma fibronectin (FN), a known master organizer of several extracellular matrix (ECM) fiber systems.
The Reinhardt group publishes novel biological mechanisms in blood vessels in PLOS Biology
Fibronectin is a protein that exists in vertebrates in two distinct forms: one present in the blood and the other in blood vessel walls. In mammals, fibronectin is important for the development of blood vessels before birth, but whether it is continuously required for blood vessel homeostasis from birth to adulthood is unknown.
Dr. John Presley co-authors a publication in Cell Reports
C24 Sphingolipids Govern the Transbilayer Asymmetry of Cholesterol and Lateral Organization of Model and Live-Cell Plasma Membranes
Cracking eggshell nanostructure
How is it that fertilized chicken eggs manage to resist fracture from the outside, while at the same time, are weak enough to break from the inside during chick hatching? It’s all in the eggshell’s nanostructure, according to a new study led by McGill University scientists.
The findings, reported today in Science Advances, could have important implications for food safety in the agro-industry.
A new, state-of-the-art gross anatomy laboratory is in the works!
A new, state-of-the-art gross anatomy laboratory is in the works! Learn more about the Strathcona Building and our plans for a cutting-edge anatomy teaching laboratory HERE!
Congratulations to Assistant Professor Dr. Huy Bui, who has been named a 2017 CIFAR Azrieli Global Scholar!
Congratulations to Assistant Professor Dr. Huy Bui, who has been named a 2017 CIFAR Azrieli Global Scholar!
Collaboration between Dr. Dieter Reinhardt and geneticist Dr. Philippe Campeau leads to the identification of a new gene
Unique collaboration of Dr. Dieter Reinhardt with geneticist Dr. Philippe Campeau at the Sainte-Justine Research Center leads to the identification of a new gene causing scoliosis and bone malformations, published in the American Journal of Human Genetics.
Have a look at the exciting 3D printing initiative taking place in Anatomy & Cell Biology!
Watch the video here!
Domingo Sarmiento Distinction awarded to Dr. Morales
Congratulations to Dr. Carlos Morales, who has been awarded the prestigious Domingo Sarmiento Distinction by the Senate of Argentina for his contributions to medical science.
Collaboration between departmental members Drs. D. Reinhardt and P. Campeau has received new 5-year funding from the Canadian Institutes of Health Research
Collaboration between departmental members Drs. D. Reinhardt and P. Campeau has received new 5-year funding from the Canadian Institutes of Health Research for the grant entitled “Role of fibronectin mutations in spondylometaphyseal dysplasia and idiopathic scoliosis” in the amount of $680,850. Congratulations!