Abstract:
Ferroptosis is form of cell death driven by peroxidation of specific lipids. I will briefly discuss the history, key regulators, recent emerging mechanisms, and therapeutic applications of controlling ferroptosis. I will describe how my lab recently identified an unusual species of lipid that is a key driver of ferroptosis, and how our studies linking ferroptosis to metabolism have enabled to design precision, therapeutic diets that promote ferroptosis in some cancer models.